1EXY

SOLUTION STRUCTURE OF HTLV-1 PEPTIDE BOUND TO ITS RNA APTAMER TARGET

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1EXY の概要

• エントリーDOI: 10.2210/pdb1exy/pdb
• 分子名称: RNA APTAMER, 33-MER, HTLV-1 REX PEPTIDE (2 entities in total)
• 機能のキーワード: arginine-guanine sandwich, extended bound basic rex peptide, flap base, junctional base triplets, rna binding pocket architecture, rna binding protein-rna complex, rna binding protein/rna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 12769.99

構造登録者

Jiang, F.,Gorin, A.,Hu, W.,Majumdar, A.,Baskerville, S.,Xu, W.,Ellington, A.,Patel, D.J. (登録日: 2000-05-05, 公開日: 2000-05-15, 最終更新日: 2024-05-22)

主引用文献

Jiang, F.,Gorin, A.,Hu, W.,Majumdar, A.,Baskerville, S.,Xu, W.,Ellington, A.,Patel, D.J.
Anchoring an extended HTLV-1 Rex peptide within an RNA major groove containing junctional base triples.
Structure Fold.Des., 7:1461-1472, 1999

PubMed Abstract: The Rex protein of the human T cell leukemia virus type 1 (HTLV-1) belongs to a family of proteins that use arginine-rich motifs (ARMs) to recognize their RNA targets. Previously, an in vitro selected RNA aptamer sequence was identified that mediates mRNA transport in vivo when placed in the primary binding site on stem-loop IID of the Rex response element. We present the solution structure of the HTLV-1 arginine-rich Rex peptide bound to its RNA aptamer target determined by multidimensional heteronuclear NMR spectroscopy.

PubMed: 10647177
DOI: 10.1016/S0969-2126(00)88337-9

実験手法

SOLUTION NMR