1ERT

HUMAN THIOREDOXIN (REDUCED FORM)

Summary for 1ERT

• Entry DOI: 10.2210/pdb1ert/pdb
• Descriptor: THIOREDOXIN (2 entities in total)
• Functional Keywords: dimer, thioredoxin, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : P10599
• Total number of polymer chains: 1
• Total formula weight: 11750.48

Authors

Weichsel, A.,Gasdaska, J.R.,Powis, G.,Montfort, W.R. (deposition date: 1996-02-07, release date: 1996-10-14, Last modification date: 2024-10-16)

Primary citation

Weichsel, A.,Gasdaska, J.R.,Powis, G.,Montfort, W.R.
Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer.
Structure, 4:735-751, 1996

PubMed Abstract: Human thioredoxin reduces the disulfide bonds of numerous proteins in vitro, and can activate transcription factors such as NFkB in vivo. Thioredoxin can also act as a growth factor, and is overexpressed and secreted in certain tumor cells.

PubMed: 8805557
DOI: 10.1016/S0969-2126(96)00079-2

Experimental method

X-RAY DIFFRACTION (1.7 Å)