1ERT

HUMAN THIOREDOXIN (REDUCED FORM)

1ERT の概要

• エントリーDOI: 10.2210/pdb1ert/pdb
• 分子名称: THIOREDOXIN (2 entities in total)
• 機能のキーワード: dimer, thioredoxin, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : P10599
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11750.48

構造登録者

Weichsel, A.,Gasdaska, J.R.,Powis, G.,Montfort, W.R. (登録日: 1996-02-07, 公開日: 1996-10-14, 最終更新日: 2024-10-16)

主引用文献

Weichsel, A.,Gasdaska, J.R.,Powis, G.,Montfort, W.R.
Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer.
Structure, 4:735-751, 1996

PubMed Abstract: Human thioredoxin reduces the disulfide bonds of numerous proteins in vitro, and can activate transcription factors such as NFkB in vivo. Thioredoxin can also act as a growth factor, and is overexpressed and secreted in certain tumor cells.

PubMed: 8805557
DOI: 10.1016/S0969-2126(96)00079-2

実験手法

X-RAY DIFFRACTION (1.7 Å)