1EPF

CRYSTAL STRUCTURE OF THE TWO N-TERMINAL IMMUNOGLOBULIN DOMAINS OF THE NEURAL CELL ADHESION MOLECULE (NCAM)

1EPF の概要

• エントリーDOI: 10.2210/pdb1epf/pdb
• 分子名称: PROTEIN (NEURAL CELL ADHESION MOLECULE), CALCIUM ION (3 entities in total)
• 機能のキーワード: ncam, immunoglobulin fold, glycoprotein, cell adhesion
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P13596
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 85669.38

構造登録者

Kasper, C.,Rasmussen, H.,Kastrup, J.S.,Ikemizu, S.,Jones, E.Y.,Berezin, V.,Bock, E.,Larsen, I.K. (登録日: 2000-03-29, 公開日: 2000-10-09, 最終更新日: 2024-11-20)

主引用文献

Kasper, C.,Rasmussen, H.,Kastrup, J.S.,Ikemizu, S.,Jones, E.Y.,Berezin, V.,Bock, E.,Larsen, I.K.
Structural basis of cell-cell adhesion by NCAM.
Nat.Struct.Biol., 7:389-393, 2000

PubMed Abstract: The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-cell recognition and adhesion via a homophilic interaction. NCAM plays a key role during development and regeneration of the nervous system and is involved in synaptic plasticity associated with memory and learning. The 1.85 A crystal structure of the two N-terminal extracellular domains of NCAM reported here provides a structural basis for the homophilic interaction. The molecular packing of the two-domain structure reveals a cross shaped antiparallel dimer, and provides fundamental insight into trans-cellular recognition mediated by NCAM.

PubMed: 10802736
DOI: 10.1038/75165

実験手法

X-RAY DIFFRACTION (1.85 Å)