1EO8
INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY
1EO8 の概要
エントリーDOI | 10.2210/pdb1eo8/pdb |
分子名称 | HEMAGGLUTININ (HA1 CHAIN), HEMAGGLUTININ (HA2 CHAIN), ANTIBODY (LIGHT CHAIN), ... (8 entities in total) |
機能のキーワード | complex (hemagglutinin-immmunoglobulin), hemagglutinin, immunoglobulin, viral protein, immune system complex, viral protein-immune system complex, viral protein/immune system |
由来する生物種 | Influenza A virus (A/X-31(H3N2)) 詳細 |
細胞内の位置 | Virion membrane ; Single-pass type I membrane protein : P03437 P03437 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 104236.02 |
構造登録者 | Fleury, D.,Gigant, B.,Daniels, R.S.,Skehel, J.J.,Knossow, M.,Bizebard, T. (登録日: 2000-03-22, 公開日: 2000-04-12, 最終更新日: 2020-07-29) |
主引用文献 | Fleury, D.,Daniels, R.S.,Skehel, J.J.,Knossow, M.,Bizebard, T. Structural evidence for recognition of a single epitope by two distinct antibodies. Proteins, 40:572-578, 2000 Cited by PubMed Abstract: The structure of a complex between the hemagglutinin of influenza virus and the Fab of a neutralizing antibody was determined by X-ray crystallography at 2.8 A resolution. This antibody and another which has only 56% sequence identity bind to the same epitope with very similar affinities and in the same orientation. One third of the interactions is conserved in the two complexes; a significant proportion of the interactions that differ are established by residues of the H3 complementarity-determining regions (CDR) which adopt distinct conformations in the two antibodies. This demonstrates that there is a definite flexibility in the selection of antibodies that bind to a given epitope, despite the high affinity of their complexes. This flexibility allows the humoral immune response to be redundant, a feature that may be useful in achieving longer lasting protection against evolving viral pathogens. PubMed: 10899782DOI: 10.1002/1097-0134(20000901)40:4<572::AID-PROT30>3.3.CO;2-E 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.8 Å) |
構造検証レポート
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