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1EO8

INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY

1EO8 の概要
エントリーDOI10.2210/pdb1eo8/pdb
分子名称HEMAGGLUTININ (HA1 CHAIN), HEMAGGLUTININ (HA2 CHAIN), ANTIBODY (LIGHT CHAIN), ... (8 entities in total)
機能のキーワードcomplex (hemagglutinin-immmunoglobulin), hemagglutinin, immunoglobulin, viral protein, immune system complex, viral protein-immune system complex, viral protein/immune system
由来する生物種Influenza A virus (A/X-31(H3N2))
詳細
細胞内の位置Virion membrane ; Single-pass type I membrane protein : P03437 P03437
タンパク質・核酸の鎖数4
化学式量合計104236.02
構造登録者
Fleury, D.,Gigant, B.,Daniels, R.S.,Skehel, J.J.,Knossow, M.,Bizebard, T. (登録日: 2000-03-22, 公開日: 2000-04-12, 最終更新日: 2020-07-29)
主引用文献Fleury, D.,Daniels, R.S.,Skehel, J.J.,Knossow, M.,Bizebard, T.
Structural evidence for recognition of a single epitope by two distinct antibodies.
Proteins, 40:572-578, 2000
Cited by
PubMed Abstract: The structure of a complex between the hemagglutinin of influenza virus and the Fab of a neutralizing antibody was determined by X-ray crystallography at 2.8 A resolution. This antibody and another which has only 56% sequence identity bind to the same epitope with very similar affinities and in the same orientation. One third of the interactions is conserved in the two complexes; a significant proportion of the interactions that differ are established by residues of the H3 complementarity-determining regions (CDR) which adopt distinct conformations in the two antibodies. This demonstrates that there is a definite flexibility in the selection of antibodies that bind to a given epitope, despite the high affinity of their complexes. This flexibility allows the humoral immune response to be redundant, a feature that may be useful in achieving longer lasting protection against evolving viral pathogens.
PubMed: 10899782
DOI: 10.1002/1097-0134(20000901)40:4<572::AID-PROT30>3.3.CO;2-E
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.8 Å)
構造検証レポート
Validation report summary of 1eo8
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-10-30に公開中

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