1EKS

ASP128ALA VARIANT OF MOAC PROTEIN FROM E. COLI

1EKS の概要

• エントリーDOI: 10.2210/pdb1eks/pdb
• 関連するPDBエントリー: 1EKR
• 分子名称: MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C, L(+)-TARTARIC ACID (3 entities in total)
• 機能のキーワード: moac, molybdenum cofactor (moco), moco biosynthesis, moco deficiency, translation
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17583.35

構造登録者

Schindelin, H.,Liu, M.T.W.,Wuebbens, M.M.,Rajagopalan, K.V. (登録日: 2000-03-09, 公開日: 2000-09-20, 最終更新日: 2024-02-07)

主引用文献

Wuebbens, M.M.,Liu, M.T.,Rajagopalan, K.,Schindelin, H.
Insights into molybdenum cofactor deficiency provided by the crystal structure of the molybdenum cofactor biosynthesis protein MoaC.
Structure Fold.Des., 8:709-718, 2000

PubMed Abstract: The molybdenum cofactor (Moco) is an essential component of a large family of enzymes involved in important transformations in carbon, nitrogen and sulfur metabolism. The Moco biosynthetic pathway is evolutionarily conserved and found in archaea, eubacteria and eukaryotes. In humans, genetic deficiencies of enzymes involved in this pathway trigger an autosomal recessive and usually deadly disease with severe neurological symptoms. The MoaC protein, together with the MoaA protein, is involved in the first step of Moco biosynthesis.

PubMed: 10903949
DOI: 10.1016/S0969-2126(00)00157-X

実験手法

X-RAY DIFFRACTION (2.5 Å)