Summary for 1EKH
| Entry DOI | 10.2210/pdb1ekh/pdb |
| Related | 1EKI |
| Descriptor | DNA (5'-D(*TP*TP*GP*GP*CP*CP*AP*A)-3'), 2,6-dideoxy-4-O-methyl-alpha-D-galactopyranose-(1-3)-4-O-acetyl-2,6-dideoxy-beta-D-galactopyranose, 3-C-methyl-4-O-acetyl-alpha-L-Olivopyranose-(1-3)-beta-D-Olivopyranose-(1-3)-beta-D-Olivopyranose, ... (5 entities in total) |
| Functional Keywords | drug bound in the minor groove of dna, dna |
| Total number of polymer chains | 2 |
| Total formula weight | 7350.72 |
| Authors | Gochin, M. (deposition date: 2000-03-08, release date: 2000-03-20, Last modification date: 2024-05-01) |
| Primary citation | Gochin, M. A high-resolution structure of a DNA-chromomycin-Co(II) complex determined from pseudocontact shifts in nuclear magnetic resonance. Structure Fold.Des., 8:441-452, 2000 Cited by PubMed Abstract: The drug chromomycin-A(3) binds to the minor groove of DNA and requires a divalent metal ion for complex formation. (1)H, (31)P and (13)C pseudocontact shifts occurring in the presence of a tightly bound divalent cobalt ion in the complex between d(TTGGCCAA)(2) and chromomycin-A(3) have been used to determine the structure of the complex. The accuracy of the structure was verified by validation with nuclear Overhauser enhancements (NOEs) and J-coupling constants not used in the structure calculation. PubMed: 10801486DOI: 10.1016/S0969-2126(00)00124-6 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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