1EJZ

SOLUTION STRUCTURE OF A HNA-RNA HYBRID

Summary for 1EJZ

• Entry DOI: 10.2210/pdb1ejz/pdb
• Related: 1EC4
• Descriptor: RNA (5'-R(*CP*GP*CP*UP*AP*CP*GP*C)-3'), DNA (5'-H(*(6HG)P*(6HC)P*(6HG)P*(6HT)P*(6HA)P*(6HG)P*(6HC)P*(6HG))-3'), PHOSPHORIC ACID MONO-(3-HYDROXY-PROPYL) ESTER (3 entities in total)
• Functional Keywords: hna-rna complex, double helix, a-type conformation, rna
• Total number of polymer chains: 2
• Total formula weight: 5237.47

Authors

Lescrnier, E.,Esnouf, R.,Heus, H.A.,Hilbers, C.W.,Herdewijn, P. (deposition date: 2000-03-06, release date: 2000-10-23, Last modification date: 2024-05-22)

Primary citation

Lescrinier, E.,Esnouf, R.,Schraml, J.,Busson, R.,Heus, H.,Hilbers, C.,Herdewijn, P.
Solution structure of a HNA-RNA hybrid.
Chem.Biol., 7:719-731, 2000

PubMed Abstract: Synthetic nucleic acid analogues with a conformationally restricted sugar-phosphate backbone are widely used in antisense strategies for biomedical and biochemical applications. The modified backbone protects the oligonucleotides against degradation within the living cell, which allows them to form stable duplexes with sequences in target mRNAs with the aim of arresting their translation. The biologically most active antisense oligonucleotides also trigger cleavage of the target RNA through activation of endogenous RNase H. Systematic studies of synthetic oligonucleotides have also been conducted to delineate the origin of the chirality of DNA and RNA that are both composed of D-nucleosides.

PubMed: 10980452
DOI: 10.1016/S1074-5521(00)00017-X

Experimental method

SOLUTION NMR