1EIS

UDA UNCOMPLEXED FORM. CRYSTAL STRUCTURE OF URTICA DIOICA AGGLUTININ, A SUPERANTIGEN PRESENTED BY MHC MOLECULES OF CLASS I AND CLASS II

1EIS の概要

• エントリーDOI: 10.2210/pdb1eis/pdb
• 関連するPDBエントリー: 1EN2 1ENM
• 分子名称: PROTEIN (AGGLUTININ ISOLECTIN VI/AGGLUTININ ISOLECTIN V) (2 entities in total)
• 機能のキーワード: lectin, hevein domain, uda, superantigen, sugar binding protein
• 由来する生物種: Urtica dioica (great nettle)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9350.27

構造登録者

Saul, F.A.,Rovira, P.,Boulot, G.,Van Damme, E.J.M.,Peumans, W.J.,Truffa-Bachi, P.,Bentley, G.A. (登録日: 2000-02-28, 公開日: 2000-06-21, 最終更新日: 2024-10-30)

主引用文献

Saul, F.A.,Rovira, P.,Boulot, G.,Damme, E.J.,Peumans, W.J.,Truffa-Bachi, P.,Bentley, G.A.
Crystal structure of Urtica dioica agglutinin, a superantigen presented by MHC molecules of class I and class II.
Structure Fold.Des., 8:593-603, 2000

PubMed Abstract: Urtica dioica agglutinin (UDA), a monomeric lectin extracted from stinging nettle rhizomes, is specific for saccharides containing N-acetylglucosamine (GlcNAc). The lectin behaves as a superantigen for murine T cells, inducing the exclusive proliferation of Vbeta8.3(+) lymphocytes. UDA is unique among known T cell superantigens because it can be presented by major histocompatibility complex (MHC) molecules of both class I and II.

PubMed: 10873861
DOI: 10.1016/S0969-2126(00)00142-8

実験手法

X-RAY DIFFRACTION (1.66 Å)