1EI3

CRYSTAL STRUCTURE OF NATIVE CHICKEN FIBRINOGEN

Summary for 1EI3

• Entry DOI: 10.2210/pdb1ei3/pdb
• Related: 1FZC
• Descriptor: FIBRINOGEN (3 entities in total)
• Functional Keywords: coiled coils, disulfide rings, fibrin forming entities, blood clotting
• Biological source: Gallus gallus (chicken); More
• Cellular location: Secreted: P14448 Q02020
• Total number of polymer chains: 6
• Total formula weight: 308324.75

Authors

Yang, Z.,Mochalkin, I.,Veerapandian, L.,Riley, M.,Doolittle, R.F. (deposition date: 2000-02-23, release date: 2000-05-10, Last modification date: 2024-02-07)

Primary citation

Yang, Z.,Mochalkin, I.,Veerapandian, L.,Riley, M.,Doolittle, R.F.
Crystal structure of native chicken fibrinogen at 5.5-A resolution.
Proc.Natl.Acad.Sci.USA, 97:3907-3912, 2000

PubMed Abstract: The crystal structure of native chicken fibrinogen has been determined at a resolution of 5.5 A. The full-length molecule is 460 A in length and sigmoidally shaped. The structure includes the full sweep of the coiled coils that connect the central and terminal domains; the chain paths of the central domain confirm a predicted scheme of planar disulfide rings in apposition with each other. Electron density maps have revealed the outlines of disordered alphaC domains nestled within the confines of the sinuous coiled coils. The amino-terminal segments of the alpha- and beta-chains, including the fibrinopeptides A and B, are also disordered.

PubMed: 10737772
DOI: 10.1073/pnas.080065697

Experimental method

X-RAY DIFFRACTION (5.5 Å)