1EI3

CRYSTAL STRUCTURE OF NATIVE CHICKEN FIBRINOGEN

1EI3 の概要

• エントリーDOI: 10.2210/pdb1ei3/pdb
• 関連するPDBエントリー: 1FZC
• 分子名称: FIBRINOGEN (3 entities in total)
• 機能のキーワード: coiled coils, disulfide rings, fibrin forming entities, blood clotting
• 由来する生物種: Gallus gallus (chicken); 詳細
• 細胞内の位置: Secreted: P14448 Q02020
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 308324.75

構造登録者

Yang, Z.,Mochalkin, I.,Veerapandian, L.,Riley, M.,Doolittle, R.F. (登録日: 2000-02-23, 公開日: 2000-05-10, 最終更新日: 2024-02-07)

主引用文献

Yang, Z.,Mochalkin, I.,Veerapandian, L.,Riley, M.,Doolittle, R.F.
Crystal structure of native chicken fibrinogen at 5.5-A resolution.
Proc.Natl.Acad.Sci.USA, 97:3907-3912, 2000

PubMed Abstract: The crystal structure of native chicken fibrinogen has been determined at a resolution of 5.5 A. The full-length molecule is 460 A in length and sigmoidally shaped. The structure includes the full sweep of the coiled coils that connect the central and terminal domains; the chain paths of the central domain confirm a predicted scheme of planar disulfide rings in apposition with each other. Electron density maps have revealed the outlines of disordered alphaC domains nestled within the confines of the sinuous coiled coils. The amino-terminal segments of the alpha- and beta-chains, including the fibrinopeptides A and B, are also disordered.

PubMed: 10737772
DOI: 10.1073/pnas.080065697

実験手法

X-RAY DIFFRACTION (5.5 Å)