1EGM

CRYSTAL STRUCTURE OF DIOL DEHYDRATASE-CYANOCOBALAMIN COMPLEX AT 100K.

1EGM の概要

• エントリーDOI: 10.2210/pdb1egm/pdb
• 関連するPDBエントリー: 1DIO 1EEX
• 分子名称: PROPANEDIOL DEHYDRATASE, POTASSIUM ION, CYANOCOBALAMIN, ... (7 entities in total)
• 機能のキーワード: cyanocobalamin, propanediol, potassium ion, tim barrel, lyase
• 由来する生物種: Klebsiella oxytoca; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 210440.14

構造登録者

Masuda, J.,Shibata, N.,Toraya, T.,Morimoto, Y.,Yasuoka, N. (登録日: 2000-02-15, 公開日: 2000-09-20, 最終更新日: 2024-02-07)

主引用文献

Masuda, J.,Shibata, N.,Morimoto, Y.,Toraya, T.,Yasuoka, N.
How a protein generates a catalytic radical from coenzyme B(12): X-ray structure of a diol-dehydratase-adeninylpentylcobalamin complex.
Structure Fold.Des., 8:775-788, 2000

PubMed Abstract: Adenosylcobalamin (coenzyme B(12)) serves as a cofactor for enzymatic radical reactions. The adenosyl radical, a catalytic radical in these reactions, is formed by homolysis of the cobalt-carbon bond of the coenzyme, although the mechanism of cleavage of its organometallic bond remains unsolved.

PubMed: 10903944
DOI: 10.1016/S0969-2126(00)00164-7

実験手法

X-RAY DIFFRACTION (1.85 Å)