1EEX

CRYSTAL STRUCTURE OF THE DIOL DEHYDRATASE-ADENINYLPENTYLCOBALAMIN COMPLEX FROM KLEBSIELLA OXYTOCA

Summary for 1EEX

• Entry DOI: 10.2210/pdb1eex/pdb
• Related: 1DIO 1EGM
• Descriptor: PROPANEDIOL DEHYDRATASE, POTASSIUM ION, CO-(ADENIN-9-YL-PENTYL)-COBALAMIN, ... (7 entities in total)
• Functional Keywords: coenzyme b12, propanediol, potassium ion, tim barrel, lyase
• Biological source: Klebsiella oxytoca; More
• Total number of polymer chains: 6
• Total formula weight: 210880.85

Authors

Shibata, N.,Masuda, J.,Toraya, T.,Morimoto, Y.,Yasuoka, N. (deposition date: 2000-02-04, release date: 2001-02-07, Last modification date: 2024-03-13)

Primary citation

Masuda, J.,Shibata, N.,Morimoto, Y.,Toraya, T.,Yasuoka, N.
How a protein generates a catalytic radical from coenzyme B(12): X-ray structure of a diol-dehydratase-adeninylpentylcobalamin complex.
Structure Fold.Des., 8:775-788, 2000

PubMed Abstract: Adenosylcobalamin (coenzyme B(12)) serves as a cofactor for enzymatic radical reactions. The adenosyl radical, a catalytic radical in these reactions, is formed by homolysis of the cobalt-carbon bond of the coenzyme, although the mechanism of cleavage of its organometallic bond remains unsolved.

PubMed: 10903944
DOI: 10.1016/S0969-2126(00)00164-7

Experimental method

X-RAY DIFFRACTION (1.7 Å)