1EDO

THE X-RAY STRUCTURE OF BETA-KETO ACYL CARRIER PROTEIN REDUCTASE FROM BRASSICA NAPUS COMPLEXED WITH NADP+

1EDO の概要

• エントリーDOI: 10.2210/pdb1edo/pdb
• 分子名称: BETA-KETO ACYL CARRIER PROTEIN REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
• 機能のキーワード: nucleotide fold, rossmann fold, oxidoreductase
• 由来する生物種: Brassica napus (rape)
• 細胞内の位置: Plastid, chloroplast (By similarity): Q93X62
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26102.82

構造登録者

Fisher, M.,Kroon, J.T.,Martindale, W.,Stuitje, A.R.,Slabas, A.R.,Rafferty, J.B. (登録日: 2000-01-28, 公開日: 2001-01-31, 最終更新日: 2024-02-07)

主引用文献

Fisher, M.,Kroon, J.T.,Martindale, W.,Stuitje, A.R.,Slabas, A.R.,Rafferty, J.B.
The X-ray structure of Brassica napus beta-keto acyl carrier protein reductase and its implications for substrate binding and catalysis.
Structure Fold.Des., 8:339-347, 2000

PubMed Abstract: beta-Keto acyl carrier protein reductase (BKR) catalyzes the pyridine-nucleotide-dependent reduction of a 3-oxoacyl form of acyl carrier protein (ACP), the first reductive step in de novo fatty acid biosynthesis and a reaction often performed in polyketide biosynthesis. The Brassica napus BKR enzyme is NADPH-dependent and forms part of a dissociable type II fatty acid synthetase (FAS). Significant sequence similarity is observed with enoyl acyl carrier protein reductase (ENR), the other reductase of FAS, and the short-chain alcohol dehydrogenase (SDR) family.

PubMed: 10801480
DOI: 10.1016/S0969-2126(00)00115-5

実験手法

X-RAY DIFFRACTION (2.3 Å)