1EB7

Crystal structure of the di-haem cytochrome c peroxidase from Pseudomonas aeruginosa

Summary for 1EB7

• Entry DOI: 10.2210/pdb1eb7/pdb
• Descriptor: CYTOCHROME C551 PEROXIDASE, HEME C, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: oxidoreductase, peroxidase, heme, electron transport
• Biological source: PSEUDOMONAS AERUGINOSA
• Cellular location: Periplasm: P14532
• Total number of polymer chains: 1
• Total formula weight: 36352.52

Authors

Fulop, V. (deposition date: 2001-07-24, release date: 2001-07-24, Last modification date: 2025-04-09)

Primary citation

Fulop, V.,Ridout, C.J.,Greenwood, C.,Hajdu, J.
Crystal Structure of the Di-Haemcytochrome C Peroxidase from Pseudomonas Aeruginosa
Structure, 3:1225-, 1995

PubMed Abstract: Cytochrome c peroxidase from Pseudomonas aeruginosa (PsCCP) represents a new class of peroxidases which work without the need to create a semi-stable free radical for catalysis. The enzyme is located in the bacterial periplasm where its likely function is to provide protection against toxic peroxides. The soluble 323-residue single polypeptide chain contains two covalent c-type haems with very different properties: one of them is a low-potential (-330 mV) centre where hydrogen peroxide is reduced (the peroxidatic site); the other is a high-potential (+320 mV) centre which feeds electrons to the peroxidatic site from soluble electron-shuttle proteins such as cytochrome c and azurin.

PubMed: 8591033
DOI: 10.1016/S0969-2126(01)00258-1

Experimental method

X-RAY DIFFRACTION (2.4 Å)