1EAI

COMPLEX OF ASCARIS CHYMOTRPSIN/ELASTASE INHIBITOR WITH PORCINE ELASTASE

1EAI の概要

• エントリーDOI: 10.2210/pdb1eai/pdb
• 分子名称: PROTEIN (ELASTASE), PROTEIN (CHYMOTRYPSIN/ELASTASE ISOINHIBITOR 1) (3 entities in total)
• 機能のキーワード: serine proteinase, elastase, ascaris summ, protein inhibitor
• 由来する生物種: Sus scrofa (pig); 詳細
• 細胞内の位置: Secreted: P00772 P07851
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 65063.08

構造登録者

Huang, K.,Strynadka, N.C.J.,Bernard, V.D.,Peanasky, R.J.,James, M.N.G. (登録日: 1999-03-25, 公開日: 1999-04-05, 最終更新日: 2024-10-09)

主引用文献

Huang, K.,Strynadka, N.C.,Bernard, V.D.,Peanasky, R.J.,James, M.N.
The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase.
Structure, 2:679-689, 1994

PubMed Abstract: The intestinal parasitic worm, Ascaris suum, produces a variety of protein inhibitors that defend the organism against the host's proteinases. Eight different proteins from Ascaris suum have been identified as inhibitors of serine proteinases, targeting chymotrypsin, elastase and trypsin. These inhibitors share 30-40% sequence identity with one another, but have virtually no sequence identity with members of any of the other families of serine proteinase inhibitors.

PubMed: 7922044
DOI: 10.1016/S0969-2126(00)00068-X

実験手法

X-RAY DIFFRACTION (2.4 Å)