1E8I

HUMAN CD69 - TETRAGONAL FORM

1E8I の概要

• エントリーDOI: 10.2210/pdb1e8i/pdb
• 関連するPDBエントリー: 1E87
• 分子名称: EARLY ACTIVATION ANTIGEN CD69, SULFATE ION (3 entities in total)
• 機能のキーワード: hematopoietic cell receptor, leucocyte, c-type lectin-like, nkd, klr
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Membrane; Single-pass type II membrane protein: Q07108
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27709.18

構造登録者

Tormo, J. (登録日: 2000-09-21, 公開日: 2000-09-26, 最終更新日: 2023-12-13)

主引用文献

Llera, A.S.,Viedma, F.,Sanchez-Madrid, F.,Tormo, J.
Crystal Structure of the C-Type Lectin-Like Domain from the Human Hematopoietic Cell Receptor Cd69
J.Biol.Chem., 276:7312-, 2001

PubMed Abstract: CD69, one of the earliest specific antigens acquired during lymphoid activation, acts as a signal-transducing receptor involved in cellular activation events, including proliferation and induction of specific genes. CD69 belongs to a family of receptors that modulate the immune response and whose genes are clustered in the natural killer (NK) gene complex. The extracellular portion of these receptors represent a subfamily of C-type lectin-like domains (CTLDs), which are divergent from true C-type lectins and are referred to as NK-cell domains (NKDs). We have determined the three-dimensional structure of human CD69 NKD in two different crystal forms. CD69 NKD adopts the canonical CTLD fold but lacks the features involved in Ca(2+) and carbohydrate binding by C-type lectins. CD69 NKD dimerizes noncovalently, both in solution and in crystalline state. The dimer interface consists of a hydrophobic, loosely packed core, surrounded by polar interactions, including an interdomain beta sheet. The intersubunit core shows certain structural plasticity that may facilitate conformational rearrangements for binding to ligands. The surface equivalent to the binding site of other members of the CTLD superfamily reveals a hydrophobic patch surrounded by conserved charged residues that probably constitutes the CD69 ligand-binding site.

PubMed: 11036086
DOI: 10.1074/JBC.M008573200

実験手法

X-RAY DIFFRACTION (1.95 Å)