1E6O

Crystal structure of Fab13B5 against HIV-1 capsid protein p24

Summary for 1E6O

• Entry DOI: 10.2210/pdb1e6o/pdb
• Related: 1A80 1AFV 1E6J 1ESK 1TAM
• Descriptor: IMMUNOGLOBULIN HEAVY CHAIN, IMMUNOGLOBULIN LIGHT CHAIN (3 entities in total)
• Functional Keywords: immunoglobulin, fab, antibody, antigen, hiv-1, p24, ca
• Biological source: MUS MUSCULUS (HOUSE MOUSE); More
• Total number of polymer chains: 2
• Total formula weight: 46838.03

Authors

Monaco-Malbet, S.,Berthet-Colominas, C.,Novelli, A.,Battai, N.,Piga, N.,Mallet, F.,Cusack, S. (deposition date: 2000-08-21, release date: 2000-11-27, Last modification date: 2023-12-13)

Primary citation

Monaco-Malbet, S.,Berthet-Colominas, C.,Novelli, A.,Battai, N.,Piga, N.,Cheynet, V.,Mallet, F.,Cusack, S.
Mutual Conformational Adaptations in Antigen and Antibody Upon Complex Formation between an Fab and HIV-1 Capsid Protein P24
Structure, 8:1069-, 2000

PubMed Abstract: Elucidating the structural basis of antigen-antibody recognition ideally requires a structural comparison of free and complexed components. To this end we have studied a mouse monoclonal antibody, denoted 13B5, raised against p24, the capsid protein of HIV-1. We have previously described the first crystal structure of intact p24 as visualized in the Fab13B5-p24 complex. Here we report the structure of the uncomplexed Fab13B5 at 1.8 A resolution and analyze the Fab-p24 interface and the conformational changes occurring upon complex formation.

PubMed: 11080628
DOI: 10.1016/S0969-2126(00)00507-4

Experimental method

X-RAY DIFFRACTION (1.8 Å)