1E5L

Apo saccharopine reductase from Magnaporthe grisea

1E5L の概要

• エントリーDOI: 10.2210/pdb1e5l/pdb
• 分子名称: SACCHAROPINE REDUCTASE (2 entities in total)
• 機能のキーワード: oxidoreductase, saccharopine reductase, lysine biosynthesis, alpha- aminoadipate pathway
• 由来する生物種: MAGNAPORTHE GRISEA (RICE BLAST FUNGUS)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 98312.52

構造登録者

Johansson, E.,Steffens, J.J.,Lindqvist, Y.,Schneider, G. (登録日: 2000-07-27, 公開日: 2000-11-27, 最終更新日: 2023-12-13)

主引用文献

Johansson, E.,Steffens, J.J.,Lindqvist, Y.,Schneider, G.
Crystal Structure of Saccharopine Reductase from Magnaporthe Grisea, an Enzyme of the Alpha-Aminoadipate Pathway of Lysine Biosynthesis
Structure, 8:1037-, 2000

PubMed Abstract: The biosynthesis of the essential amino acid lysine in higher fungi and cyanobacteria occurs via the alpha-aminoadipate pathway, which is completely different from the lysine biosynthetic pathway found in plants and bacteria. The penultimate reaction in the alpha-aminoadipate pathway is catalysed by NADPH-dependent saccharopine reductase. We set out to determine the structure of this enzyme as a first step in exploring the structural biology of fungal lysine biosynthesis.

PubMed: 11080625
DOI: 10.1016/S0969-2126(00)00512-8

実験手法

X-RAY DIFFRACTION (2.4 Å)