1E4G

FtsA (ATP-bound form) from Thermotoga maritima

1E4G の概要

• エントリーDOI: 10.2210/pdb1e4g/pdb
• 関連するPDBエントリー: 1E4F
• 分子名称: CELL DIVISION PROTEIN FTSA, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: bacterial cell division, actin family
• 由来する生物種: THERMOTOGA MARITIMA
• 細胞内の位置: Cell inner membrane ; Peripheral membrane protein ; Cytoplasmic side : Q9WZU0
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 47935.49

構造登録者

van den Ent, F.,Lowe, J. (登録日: 2000-07-03, 公開日: 2000-10-18, 最終更新日: 2024-10-23)

主引用文献

van den Ent, F.,Lowe, J.
Crystal Structure of the Cell Division Protein Ftsa from Thermotoga Maritima
Embo J., 19:5300-, 2000

PubMed Abstract: Bacterial cell division requires formation of a septal ring. A key step in septum formation is polymerization of FtsZ. FtsA directly interacts with FtsZ and probably targets other proteins to the septum. We have solved the crystal structure of FtsA from Thermotoga maritima in the apo and ATP-bound form. FtsA consists of two domains with the nucleotide-binding site in the interdomain cleft. Both domains have a common core that is also found in the actin family of proteins. Structurally, FtsA is most homologous to actin and heat-shock cognate protein (Hsc70). An important difference between FtsA and the actin family of proteins is the insertion of a subdomain in FtsA. Movement of this subdomain partially encloses a groove, which could bind the C-terminus of FtsZ. FtsZ is the bacterial homologue of tubulin, and the FtsZ ring is functionally similar to the contractile ring in dividing eukaryotic cells. Elucidation of the crystal structure of FtsA shows that another bacterial protein involved in cytokinesis is structurally related to a eukaryotic cytoskeletal protein involved in cytokinesis.

PubMed: 11032797
DOI: 10.1093/EMBOJ/19.20.5300

実験手法

X-RAY DIFFRACTION (2.6 Å)