1E1A

Crystal structure of DFPase from Loligo vulgaris

Summary for 1E1A

• Entry DOI: 10.2210/pdb1e1a/pdb
• Descriptor: DIISOPROPYLFLUOROPHOSPHATASE, CALCIUM ION (3 entities in total)
• Functional Keywords: phosphotriesterase, calcium-binding site, phosphotriesterase (pte), selenometionine, beta-propeller
• Biological source: LOLIGO VULGARIS (SQUID)
• Total number of polymer chains: 1
• Total formula weight: 35200.87

Authors

Koepke, J.,Scharff, E.I.,Fritzsch, G.,Luecke, C.,Rueterjans, H. (deposition date: 2000-04-28, release date: 2001-06-06, Last modification date: 2024-05-08)

Primary citation

Scharff, E.I.,Koepke, J.,Fritzsch, G.,Luecke, C.,Rueterjans, H.
Crystal Structure of Diisopropylfluorophosphatase from Loligo Vulgaris
Structure, 9:493-, 2001

PubMed Abstract: Phosphotriesterases (PTE) are enzymes capable of detoxifying organophosphate-based chemical warfare agents by hydrolysis. One subclass of these enzymes comprises the family of diisopropylfluorophosphatases (DFPases). The DFPase reported here was originally isolated from squid head ganglion of Loligo vulgaris and can be characterized as squid-type DFPase. It is capable of hydrolyzing the organophosphates diisopropylfluorophosphate, soman, sarin, tabun, and cyclosarin.

PubMed: 11435114
DOI: 10.1016/S0969-2126(01)00610-4

Experimental method

X-RAY DIFFRACTION (1.8 Å)