1E0L

FBP28WW domain from Mus musculus

1E0L の概要

• エントリーDOI: 10.2210/pdb1e0l/pdb
• 関連するPDBエントリー: 1E0M 1E0N
• 分子名称: FORMIN BINDING PROTEIN (1 entity in total)
• 機能のキーワード: sh3 domain, ww domain, fbp28, signal transduction
• 由来する生物種: MUS MUSCULUS (HOUSE MOUSE)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 4364.71

構造登録者

Macias, M.J.,Gervais, V.,Civera, C.,Oschkinat, H. (登録日: 2000-03-30, 公開日: 2000-04-20, 最終更新日: 2024-05-15)

主引用文献

Macias, M.J.,Gervais, V.,Civera, C.,Oschkinat, H.
Structural Analysis of Ww Domains and Design of a Ww Prototype
Nat.Struct.Biol., 7:375-, 2000

PubMed Abstract: Two new NMR structures of WW domains, the mouse formin binding protein and a putative 84.5 kDa protein from Saccharomyces cerevisiae, show that this domain, only 35 amino acids in length, defines the smallest monomeric triple-stranded antiparallel beta-sheet protein domain that is stable in the absence of disulfide bonds, tightly bound ions or ligands. The structural roles of conserved residues have been studied using site-directed mutagenesis of both wild type domains. Crucial interactions responsible for the stability of the WW structure have been identified. Based on a network of highly conserved long range interactions across the beta-sheet structure that supports the WW fold and on a systematic analysis of conserved residues in the WW family, we have designed a folded prototype WW sequence.

PubMed: 10802733
DOI: 10.1038/75144

実験手法

SOLUTION NMR