1DZI

integrin alpha2 I domain / collagen complex

Summary for 1DZI

• Entry DOI: 10.2210/pdb1dzi/pdb
• Related: 1AOX
• Descriptor: INTEGRIN, COLLAGEN, COBALT (II) ION, ... (4 entities in total)
• Functional Keywords: integrin, collagen
• Biological source: HOMO SAPIENS; More
• Cellular location: Membrane; Single-pass type I membrane protein: P17301
• Total number of polymer chains: 4
• Total formula weight: 26457.38

Authors

Emsley, j.,Knight, G.,Farndale, R.,Barnes, M.,Liddington, R. (deposition date: 2000-03-01, release date: 2001-03-01, Last modification date: 2025-04-09)

Primary citation

Emsley, J.,Knight, G.,Farndale, R.,Barnes, M.,Liddington, R.
Structural Basis of Collagen Recognition by Integrin Alpha2Beta1
Cell(Cambridge,Mass.), 101:47-, 2000

PubMed Abstract: We have determined the crystal structure of a complex between the I domain of integrin alpha2beta1 and a triple helical collagen peptide containing a critical GFOGER motif. Three loops on the upper surface of the I domain that coordinate a metal ion also engage the collagen, with a collagen glutamate completing the coordination sphere of the metal. Comparison with the unliganded I domain reveals a change in metal coordination linked to a reorganization of the upper surface that together create a complementary surface for binding collagen. Conformational changes propagate from the upper surface to the opposite pole of the domain, suggesting both a basis for affinity regulation and a pathway for signal transduction. The structural features observed here may represent a general mechanism for integrin-ligand recognition.

PubMed: 10778855
DOI: 10.1016/S0092-8674(00)80622-4

Experimental method

X-RAY DIFFRACTION (2.1 Å)