1DSM

(-)-duocarmycin SA covalently linked to duplex DNA

Summary for 1DSM

• Entry DOI: 10.2210/pdb1dsm/pdb
• Descriptor: 5'-D(*GP*AP*CP*TP*AP*AP*TP*TP*GP*AP*C)-3', 5'-D(*GP*TP*CP*AP*AP*TP*TP*AP*GP*TP*C)-3', 4-HYDROXY-8-METHYL-6-(4,5,6-TRIMETHOXY-1H-INDOLE-2-CARBONYL)-3,6,7,8-TETRAHYDRO-3,6-DIAZA-AS-INDACENE-2-CARBOXYLIC ACID METHYL ESTER (3 entities in total)
• Functional Keywords: duocarmycin, dna, minor groove binding, antitumor agent, drug-dna complex
• Total number of polymer chains: 2
• Total formula weight: 7184.91

Authors

Smith, J.A.,Case, D.A.,Chazin, W.J. (deposition date: 1999-03-27, release date: 1999-04-02, Last modification date: 2023-12-27)

• Primary citation: Smith, J.A.,Bifulco, G.,Case, D.A.,Boger, D.L.,Gomez-Paloma, L.,Chazin, W.J.; The structural basis for in situ activation of DNA alkylation by duocarmycin SA; J.Mol.Biol., 300:1195-1204, 2000; PubMed: 10903864; DOI: 10.1006/jmbi.2000.3887

Experimental method

SOLUTION NMR