1DSM
(-)-duocarmycin SA covalently linked to duplex DNA
Summary for 1DSM
Entry DOI | 10.2210/pdb1dsm/pdb |
Descriptor | 5'-D(*GP*AP*CP*TP*AP*AP*TP*TP*GP*AP*C)-3', 5'-D(*GP*TP*CP*AP*AP*TP*TP*AP*GP*TP*C)-3', 4-HYDROXY-8-METHYL-6-(4,5,6-TRIMETHOXY-1H-INDOLE-2-CARBONYL)-3,6,7,8-TETRAHYDRO-3,6-DIAZA-AS-INDACENE-2-CARBOXYLIC ACID METHYL ESTER (3 entities in total) |
Functional Keywords | duocarmycin, dna, minor groove binding, antitumor agent, drug-dna complex |
Total number of polymer chains | 2 |
Total formula weight | 7184.91 |
Authors | Smith, J.A.,Case, D.A.,Chazin, W.J. (deposition date: 1999-03-27, release date: 1999-04-02, Last modification date: 2023-12-27) |
Primary citation | Smith, J.A.,Bifulco, G.,Case, D.A.,Boger, D.L.,Gomez-Paloma, L.,Chazin, W.J. The structural basis for in situ activation of DNA alkylation by duocarmycin SA J.Mol.Biol., 300:1195-1204, 2000 Cited by PubMed: 10903864DOI: 10.1006/jmbi.2000.3887 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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