1DSI
Solution structure of a duocarmycin sa-indole-alkylated dna dupleX
Summary for 1DSI
Entry DOI | 10.2210/pdb1dsi/pdb |
Descriptor | DNA (5'-D(*GP*AP*CP*TP*AP*AP*TP*TP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*AP*AP*TP*TP*AP*GP*TP*C)-3'), 4-HYDROXY-6-(1H-INDOLE-2-CARBONYL)-8-METHYL-3,6,7,8-TETRAHYDRO-3,6-DIAZA-AS-INDACENE-2-CARBOXYLIC ACID METHYL ESTER (3 entities in total) |
Functional Keywords | deoxyribonucleic acid, duocarmycin, dna, minor groove binding, antitumor agent, ligand-dna complex |
Total number of polymer chains | 2 |
Total formula weight | 7094.84 |
Authors | Schnell, J.R.,Ketchem, R.R.,Boger, D.L.,Chazin, W.J. (deposition date: 1998-07-29, release date: 1998-08-05, Last modification date: 2024-05-22) |
Primary citation | Schnell, J.R.,Ketchem, R.R.,Boger, D.L.,Chazin, W.J. Binding-Induced Activation of DNA Alkylation by Duocarmycin SA: Insights from the Structure of an Indole Derivative-DNA Adduct J.Am.Chem.Soc., 121:5645-5652, 1999 Cited by DOI: 10.1021/ja983556jPDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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