1DRS

THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN

Summary for 1DRS

Entry DOI	10.2210/pdb1drs/pdb
Descriptor	DENDROASPIN (1 entity in total)
Functional Keywords	cell adhesion protein
Biological source	Dendroaspis jamesoni kaimosae (eastern Jameson's mamba)
Total number of polymer chains	1
Total formula weight	6761.68
Authors	Sutcliffe, M.J.,Jaseja, M.,Hyde, E.I.,Lu, X.,Williams, J.A. (deposition date: 1994-09-29, release date: 1994-12-20, Last modification date: 2024-10-30)
Primary citation	Sutcliffe, M.J.,Jaseja, M.,Hyde, E.I.,Lu, X.,Williams, J.A. Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspin. Nat.Struct.Biol., 1:802-807, 1994 Cited by PubMed Abstract: Dendroaspin is a short chain neurotoxin homologue from the venom of Elapidae snakes, which lacks neurotoxicity. Unlike neurotoxins, it contains an Arg-Gly-Asp-(RGD)-motif and functions as an inhibitor of platelet aggregation and platelet adhesion with comparable potency to the disintegrins from the venoms of Viperidae. We have determined the structure of dendroaspin in solution using NMR spectroscopy. The structure contains a core similar to that of short chain neurotoxins, but with a novel arrangement of loops and a solvent-exposed RGD-motif. Dendroaspin is thus an integrin antagonist with a well defined fold different from that of the disintegrins, based on the neurotoxin scaffold. PubMed: 7634091 DOI: 10.1038/nsb1194-802 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation