1DRS

THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN

1DRS の概要

• エントリーDOI: 10.2210/pdb1drs/pdb
• 分子名称: DENDROASPIN (1 entity in total)
• 機能のキーワード: cell adhesion protein
• 由来する生物種: Dendroaspis jamesoni kaimosae (eastern Jameson's mamba)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 6761.68

構造登録者

Sutcliffe, M.J.,Jaseja, M.,Hyde, E.I.,Lu, X.,Williams, J.A. (登録日: 1994-09-29, 公開日: 1994-12-20, 最終更新日: 2024-10-30)

主引用文献

Sutcliffe, M.J.,Jaseja, M.,Hyde, E.I.,Lu, X.,Williams, J.A.
Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspin.
Nat.Struct.Biol., 1:802-807, 1994

PubMed Abstract: Dendroaspin is a short chain neurotoxin homologue from the venom of Elapidae snakes, which lacks neurotoxicity. Unlike neurotoxins, it contains an Arg-Gly-Asp-(RGD)-motif and functions as an inhibitor of platelet aggregation and platelet adhesion with comparable potency to the disintegrins from the venoms of Viperidae. We have determined the structure of dendroaspin in solution using NMR spectroscopy. The structure contains a core similar to that of short chain neurotoxins, but with a novel arrangement of loops and a solvent-exposed RGD-motif. Dendroaspin is thus an integrin antagonist with a well defined fold different from that of the disintegrins, based on the neurotoxin scaffold.

PubMed: 7634091
DOI: 10.1038/nsb1194-802

実験手法

SOLUTION NMR