1DRO

NMR STRUCTURE OF THE CYTOSKELETON/SIGNAL TRANSDUCTION PROTEIN

1DRO の概要

• エントリーDOI: 10.2210/pdb1dro/pdb
• 分子名称: BETA-SPECTRIN (1 entity in total)
• 機能のキーワード: cytoskeleton
• 由来する生物種: Drosophila melanogaster (fruit fly)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13583.06

構造登録者

Zhang, P.,Talluri, S.,Deng, H.,Branton, D.,Wagner, G. (登録日: 1995-09-29, 公開日: 1996-04-03, 最終更新日: 2024-05-22)

主引用文献

Zhang, P.,Talluri, S.,Deng, H.,Branton, D.,Wagner, G.
Solution structure of the pleckstrin homology domain of Drosophila beta-spectrin.
Structure, 3:1185-1195, 1995

PubMed Abstract: The pleckstrin homology (PH) domain, which is approximately 100 amino acids long, has been found in about 70 proteins involved in signal transduction and cytoskeletal function, a frequency comparable to SH2 (src homology 2) and SH3 domains. PH domains have been shown to bind the beta gamma-subunits of G-proteins and phosphatidylinositol 4,5-bisphosphate (PIP2). It is conceivable that the PH domain of beta-spectrin plays a part in the association of spectrin with the plasma membrane of cells.

PubMed: 8591029
DOI: 10.1016/S0969-2126(01)00254-4

実験手法

SOLUTION NMR