1DOH

STRUCTURE OF TRIHYDROXYNAPHTHALENE REDUCTASE IN COMPLEX WITH NADPH AND 4-NITRO-INDEN-1-ONE

1DOH の概要

• エントリーDOI: 10.2210/pdb1doh/pdb
• 関連するPDBエントリー: 1YBV
• 分子名称: TRIHYDROXYNAPHTHALENE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-NITRO-INDEN-1-ONE, ... (4 entities in total)
• 機能のキーワード: protein-nadph-active site inhibitor complex, dinucleotide binding fold, oxidoreductase
• 由来する生物種: Magnaporthe grisea
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62196.49

構造登録者

Liao, D.I.,Basarab, G.S.,Gatenby, A.A.,Jordan, D.B. (登録日: 1999-12-20, 公開日: 2001-06-06, 最終更新日: 2024-02-07)

主引用文献

Liao, D.,Basarab, G.S.,Gatenby, A.A.,Valent, B.,Jordan, D.B.
Structures of trihydroxynaphthalene reductase-fungicide complexes: implications for structure-based design and catalysis.
Structure, 9:19-28, 2001

PubMed Abstract: Trihydroxynaphthalene reductase catalyzes two intermediate steps in the fungal melanin biosynthetic pathway. The enzyme, a typical short-chain dehydrogenase, is the biochemical target of three commercial fungicides. The fungicides bind preferentially to the NADPH form of the enzyme.

PubMed: 11342131
DOI: 10.1016/S0969-2126(00)00548-7

実験手法

X-RAY DIFFRACTION (2.1 Å)