1DMP

STRUCTURE OF HIV-1 PROTEASE COMPLEX

Summary for 1DMP

Entry DOI	10.2210/pdb1dmp/pdb
Descriptor	HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-1,3-BIS([(3-AMINO)PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)-2H-1,3-DIAZEPINONE (2 entities in total)
Functional Keywords	aids, polyprotein, hydrolase, aspartyl protease, acid protease, rna-directed dna polymerase, endonuclease, aspartyl proteinase
Biological source	Human immunodeficiency virus 1
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
Total number of polymer chains	2
Total formula weight	22083.99
Authors	Chang, C.-H. (deposition date: 1996-11-01, release date: 1997-11-12, Last modification date: 2023-08-09)
Primary citation	Hodge, C.N.,Aldrich, P.E.,Bacheler, L.T.,Chang, C.H.,Eyermann, C.J.,Garber, S.,Grubb, M.,Jackson, D.A.,Jadhav, P.K.,Korant, B.,Lam, P.Y.,Maurin, M.B.,Meek, J.L.,Otto, M.J.,Rayner, M.M.,Reid, C.,Sharpe, T.R.,Shum, L.,Winslow, D.L.,Erickson-Viitanen, S. Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450. Chem.Biol., 3:301-314, 1996 Cited by PubMed: 8807858 DOI: 10.1016/S1074-5521(96)90110-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation