1DMP

STRUCTURE OF HIV-1 PROTEASE COMPLEX

1DMP の概要

• エントリーDOI: 10.2210/pdb1dmp/pdb
• 分子名称: HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-1,3-BIS([(3-AMINO)PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)-2H-1,3-DIAZEPINONE (2 entities in total)
• 機能のキーワード: aids, polyprotein, hydrolase, aspartyl protease, acid protease, rna-directed dna polymerase, endonuclease, aspartyl proteinase
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22083.99

構造登録者

Chang, C.-H. (登録日: 1996-11-01, 公開日: 1997-11-12, 最終更新日: 2024-11-20)

主引用文献

Hodge, C.N.,Aldrich, P.E.,Bacheler, L.T.,Chang, C.H.,Eyermann, C.J.,Garber, S.,Grubb, M.,Jackson, D.A.,Jadhav, P.K.,Korant, B.,Lam, P.Y.,Maurin, M.B.,Meek, J.L.,Otto, M.J.,Rayner, M.M.,Reid, C.,Sharpe, T.R.,Shum, L.,Winslow, D.L.,Erickson-Viitanen, S.
Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450.
Chem.Biol., 3:301-314, 1996

PubMed Abstract: Effective HIV protease inhibitors must combine potency towards wild-type and mutant variants of HIV with oral bioavailability such that drug levels in relevant tissues continuously exceed that required for inhibition of virus replication. Computer-aided design led to the discovery of cyclic urea inhibitors of the HIV protease. We set out to improve the physical properties and oral bioavailability of these compounds.

PubMed: 8807858
DOI: 10.1016/S1074-5521(96)90110-6

実験手法

X-RAY DIFFRACTION (2 Å)