1DMK

BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 4-AMINO-6-PHENYL-TETRAHYDROPTERIDINE

Summary for 1DMK

• Entry DOI: 10.2210/pdb1dmk/pdb
• Related: 1NSE
• Descriptor: NITRIC OXIDE SYNTHASE, ACETATE ION, CACODYLATE ION, ... (8 entities in total)
• Functional Keywords: alpha-beta fold, oxidoreductase
• Biological source: Bos taurus (cattle)
• Cellular location: Cell membrane: P29473
• Total number of polymer chains: 2
• Total formula weight: 102098.79

Authors

Kotsonis, P.,Frohlich, L.G.,Raman, C.S.,Li, H.,Berg, M.,Gerwig, R.,Groehn, V.,Kang, Y.,Al-Masoudi, N.,Taghavi-Moghadam, S.,Mohr, D.,Munch, U.,Schnabel, J.,Martasek, P.,Masters, B.S.,Strobel, H.,Poulos, T.,Matter, H.,Pfleiderer, W.,Schmidt, H.H. (deposition date: 1999-12-14, release date: 2000-12-20, Last modification date: 2024-02-07)

• Primary citation: Kotsonis, P.,Frohlich, L.G.,Raman, C.S.,Li, H.,Berg, M.,Gerwig, R.,Groehn, V.,Kang, Y.,Al-Masoudi, N.,Taghavi-Moghadam, S.,Mohr, D.,Munch, U.,Schnabel, J.,Martasek, P.,Masters, B.S.,Strobel, H.,Poulos, T.,Matter, H.,Pfleiderer, W.,Schmidt, H.H.; Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin; J.Biol.Chem., 276:49133-49141, 2001; PubMed: 11590164; DOI: 10.1074/jbc.M011469200

Experimental method

X-RAY DIFFRACTION (1.9 Å)