1DM2

HUMAN CYCLIN-DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR HYMENIALDISINE

Summary for 1DM2

DescriptorCYCLIN-DEPENDENT KINASE 2, 4-(5-AMINO-4-OXO-4H-PYRAZOL-3-YL)-2-BROMO-4,5,6,7-TETRAHYDRO-3AH-PYRROLO[2,3-C]AZEPIN-8-ONE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsprotein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome P24941
Total number of polymer chains1
Total molecular weight34548.89
Authors
Thunnissen, A.M.,Kim, S.-H. (deposition date: 1999-12-13, release date: 2000-05-31, Last modification date: 2018-01-31)
Primary citation
Meijer, L.,Thunnissen, A.M.,White, A.W.,Garnier, M.,Nikolic, M.,Tsai, L.H.,Walter, J.,Cleverley, K.E.,Salinas, P.C.,Wu, Y.Z.,Biernat, J.,Mandelkow, E.M.,Kim, S.H.,Pettit, G.R.
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.
Chem.Biol., 7:51-63, 2000
PubMed: 10662688 (PDB entries with the same primary citation)
DOI: 10.1016/S1074-5521(00)00063-6
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers1609.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report