1DM2

HUMAN CYCLIN-DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR HYMENIALDISINE

Summary for 1DM2

• Entry DOI: 10.2210/pdb1dm2/pdb
• Descriptor: CYCLIN-DEPENDENT KINASE 2, 4-(5-AMINO-4-OXO-4H-PYRAZOL-3-YL)-2-BROMO-4,5,6,7-TETRAHYDRO-3AH-PYRROLO[2,3-C]AZEPIN-8-ONE, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
• Total number of polymer chains: 1
• Total formula weight: 34548.89

Authors

Thunnissen, A.M.,Kim, S.-H. (deposition date: 1999-12-13, release date: 2000-05-31, Last modification date: 2024-02-07)

Primary citation

Meijer, L.,Thunnissen, A.M.,White, A.W.,Garnier, M.,Nikolic, M.,Tsai, L.H.,Walter, J.,Cleverley, K.E.,Salinas, P.C.,Wu, Y.Z.,Biernat, J.,Mandelkow, E.M.,Kim, S.H.,Pettit, G.R.
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.
Chem.Biol., 7:51-63, 2000

PubMed Abstract: Over 2000 protein kinases regulate cellular functions. Screening for inhibitors of some of these kinases has already yielded some potent and selective compounds with promising potential for the treatment of human diseases.

PubMed: 10662688
DOI: 10.1016/S1074-5521(00)00063-6

Experimental method

X-RAY DIFFRACTION (2.1 Å)