Summary for 1DM2
| Descriptor | CYCLIN-DEPENDENT KINASE 2, 4-(5-AMINO-4-OXO-4H-PYRAZOL-3-YL)-2-BROMO-4,5,6,7-TETRAHYDRO-3AH-PYRROLO[2,3-C]AZEPIN-8-ONE, 1,2-ETHANEDIOL, ... (4 entities in total) |
|---|---|
| Functional Keywords | protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome P24941 |
| Total number of polymer chains | 1 |
| Total molecular weight | 34548.89 |
| Authors | Thunnissen, A.M.,Kim, S.-H. (deposition date: 1999-12-13, release date: 2000-05-31, Last modification date: 2018-01-31) |
| Primary citation | Meijer, L.,Thunnissen, A.M.,White, A.W.,Garnier, M.,Nikolic, M.,Tsai, L.H.,Walter, J.,Cleverley, K.E.,Salinas, P.C.,Wu, Y.Z.,Biernat, J.,Mandelkow, E.M.,Kim, S.H.,Pettit, G.R. Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Chem.Biol., 7:51-63, 2000 PubMed: 10662688 (PDB entries with the same primary citation) DOI: 10.1016/S1074-5521(00)00063-6  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
