1DM2

HUMAN CYCLIN-DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR HYMENIALDISINE

1DM2 の概要

分子名称CYCLIN-DEPENDENT KINASE 2, 4-(5-AMINO-4-OXO-4H-PYRAZOL-3-YL)-2-BROMO-4,5,6,7-TETRAHYDRO-3AH-PYRROLO[2,3-C]AZEPIN-8-ONE, 1,2-ETHANEDIOL, ... (4 entities in total)
機能のキーワードprotein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition
由来する生物種Homo sapiens (human)
細胞内の位置Cytoplasm, cytoskeleton, microtubule organizing center, centrosome P24941
ポリマー鎖数1
分子量合計34548.89
構造登録者
Thunnissen, A.M.,Kim, S.-H. (登録日: 1999-12-13, 公開日: 2000-05-31, 最終更新日: 2018-01-31)
主引用文献
Meijer, L.,Thunnissen, A.M.,White, A.W.,Garnier, M.,Nikolic, M.,Tsai, L.H.,Walter, J.,Cleverley, K.E.,Salinas, P.C.,Wu, Y.Z.,Biernat, J.,Mandelkow, E.M.,Kim, S.H.,Pettit, G.R.
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.
Chem.Biol., 7:51-63, 2000
PubMed: 10662688 (主引用文献が同じPDBエントリー)
DOI: 10.1016/S1074-5521(00)00063-6
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.1 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers1609.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード