1DM2

HUMAN CYCLIN-DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR HYMENIALDISINE

1DM2 の概要

• エントリーDOI: 10.2210/pdb1dm2/pdb
• 分子名称: CYCLIN-DEPENDENT KINASE 2, 4-(5-AMINO-4-OXO-4H-PYRAZOL-3-YL)-2-BROMO-4,5,6,7-TETRAHYDRO-3AH-PYRROLO[2,3-C]AZEPIN-8-ONE, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34548.89

構造登録者

Thunnissen, A.M.,Kim, S.-H. (登録日: 1999-12-13, 公開日: 2000-05-31, 最終更新日: 2024-02-07)

主引用文献

Meijer, L.,Thunnissen, A.M.,White, A.W.,Garnier, M.,Nikolic, M.,Tsai, L.H.,Walter, J.,Cleverley, K.E.,Salinas, P.C.,Wu, Y.Z.,Biernat, J.,Mandelkow, E.M.,Kim, S.H.,Pettit, G.R.
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.
Chem.Biol., 7:51-63, 2000

PubMed Abstract: Over 2000 protein kinases regulate cellular functions. Screening for inhibitors of some of these kinases has already yielded some potent and selective compounds with promising potential for the treatment of human diseases.

PubMed: 10662688
DOI: 10.1016/S1074-5521(00)00063-6

実験手法

X-RAY DIFFRACTION (2.1 Å)