1DLL

The HC fragement of tetanus toxin complexed with lactose

Summary for 1DLL

Entry DOI	10.2210/pdb1dll/pdb
Related	1A8D 1AF9
Related PRD ID	PRD_900004
Descriptor	TETANUS TOXIN, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, GLYCEROL, ... (4 entities in total)
Functional Keywords	beta trefoil, jelly roll, toxin
Biological source	Clostridium tetani
Total number of polymer chains	1
Total formula weight	51187.59
Authors	Emsley, P.,Fotinou, C.,Black, I.,Fairweather, N.F.,Charles, I.G.,Watts, C.,Hewitt, E.,Isaacs, N.W. (deposition date: 1999-12-10, release date: 2000-03-24, Last modification date: 2024-02-07)
Primary citation	Emsley, P.,Fotinou, C.,Black, I.,Fairweather, N.F.,Charles, I.G.,Watts, C.,Hewitt, E.,Isaacs, N.W. The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding. J.Biol.Chem., 275:8889-8894, 2000 Cited by PubMed Abstract: The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding of the toxin to gangliosides on the cell surface. The carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin contains the ganglioside-binding site, which has not yet been fully characterized. The crystal structures of native H(C) and of H(C) soaked with carbohydrates reveal a number of binding sites and provide insight into the possible mode of ganglioside binding. PubMed: 10722735 DOI: 10.1074/jbc.275.12.8889 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation