1DIW

THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH GALACTOSE

1DIW の概要

• エントリーDOI: 10.2210/pdb1diw/pdb
• 関連するPDBエントリー: 1A8D 1AF9 1DFQ
• 分子名称: TETANUS TOXIN HC, beta-D-galactopyranose (3 entities in total)
• 機能のキーワード: beta trefoil, jelly-roll, toxin
• 由来する生物種: Clostridium tetani
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 50699.11

構造登録者

Emsley, P.,Fotinou, C.,Black, I.,Fairweather, N.F.,Charles, I.G.,Watts, C.,Hewitt, E.,Isaacs, N.W. (登録日: 1999-11-30, 公開日: 2000-03-24, 最終更新日: 2024-02-07)

主引用文献

Emsley, P.,Fotinou, C.,Black, I.,Fairweather, N.F.,Charles, I.G.,Watts, C.,Hewitt, E.,Isaacs, N.W.
The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding.
J.Biol.Chem., 275:8889-8894, 2000

PubMed Abstract: The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding of the toxin to gangliosides on the cell surface. The carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin contains the ganglioside-binding site, which has not yet been fully characterized. The crystal structures of native H(C) and of H(C) soaked with carbohydrates reveal a number of binding sites and provide insight into the possible mode of ganglioside binding.

PubMed: 10722735
DOI: 10.1074/jbc.275.12.8889

実験手法

X-RAY DIFFRACTION (2 Å)