1DEN

PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS

1DEN の概要

• エントリーDOI: 10.2210/pdb1den/pdb
• 分子名称: DENDROTOXIN I (1 entity in total)
• 機能のキーワード: venom(potassium channel inhibitor)
• 由来する生物種: Dendroaspis polylepis polylepis (black mamba)
• 細胞内の位置: Secreted: P00979
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 7170.41

構造登録者

Lancelin, J.-M.,Foray, M.-F. (登録日: 1994-03-07, 公開日: 1994-05-31, 最終更新日: 2024-11-13)

主引用文献

Lancelin, J.M.,Foray, M.F.,Poncin, M.,Hollecker, M.,Marion, D.
Proteinase inhibitor homologues as potassium channel blockers.
Nat.Struct.Biol., 1:246-250, 1994

PubMed Abstract: We report here the NMR structure of dendrotoxin I, a powerful potassium channel blocker from the venom of the African Elapidae snake Dendroaspis polylepis polylepis (black mamba), calculated from an experimentally-derived set of 719 geometric restraints. The backbone of the toxin superimposes on bovine pancreatic trypsin inhibitor (BPTI) with a root-mean-square deviation of < 1.7 A. The surface electrostatic potential calculated for dendrotoxin I and BPTI, reveal an important difference which might account for the differences in function of the two proteins. These proteins may provide examples of adaptation for specific and diverse biological functions while at the same time maintaining the overall three-dimensional structure of a common ancestor.

PubMed: 7544683
DOI: 10.1038/nsb0494-246

実験手法

SOLUTION NMR