1DCI

DIENOYL-COA ISOMERASE

1DCI の概要

• エントリーDOI: 10.2210/pdb1dci/pdb
• 分子名称: DIENOYL-COA ISOMERASE, SULFATE ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: lyase, dienoyl-coa isomerase
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Mitochondrion: Q62651
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 92548.37

構造登録者

Modis, Y.,Filppula, S.A.,Novikov, D.,Norledge, B.,Hiltunen, J.K.,Wierenga, R.K. (登録日: 1998-02-13, 公開日: 1999-03-30, 最終更新日: 2024-02-07)

主引用文献

Modis, Y.,Filppula, S.A.,Novikov, D.K.,Norledge, B.,Hiltunen, J.K.,Wierenga, R.K.
The crystal structure of dienoyl-CoA isomerase at 1.5 A resolution reveals the importance of aspartate and glutamate sidechains for catalysis.
Structure, 6:957-970, 1998

PubMed Abstract: The degradation of unsaturated fatty acids is vital to all living organisms. Certain unsaturated fatty acids must be catabolized via a pathway auxiliary to the main beta-oxidation pathway. Dienoyl-coenzyme A (dienoyl-CoA) isomerase catalyzes one step of this auxiliary pathway, the isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, and is imported into both mitochondria and peroxisomes. Dienoyl-CoA isomerase belongs to a family of CoA-binding proteins that share the enoyl-CoA hydratase/isomerase sequence motif.

PubMed: 9739087
DOI: 10.1016/S0969-2126(98)00098-7

実験手法

X-RAY DIFFRACTION (1.5 Å)