1DAJ

COMPARISON OF TERNARY COMPLEXES OF PNEUMOCYSTIS CARINII AND WILD TYPE HUMAN DIHYDROFOLATE REDUCTASE WITH COENZYME NADPH AND A NOVEL CLASSICAL ANTITUMOR FURO[2,3D]PYRIMIDINE ANTIFOLATE

Summary for 1DAJ

Entry DOI	10.2210/pdb1daj/pdb
Descriptor	DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE, ... (4 entities in total)
Functional Keywords	oxidoreductase
Biological source	Pneumocystis carinii
Total number of polymer chains	1
Total formula weight	25106.38
Authors	Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Gangjee, A.,Devraj, R.,Queener, S.F.,Blakley, R.L. (deposition date: 1997-07-29, release date: 1997-12-24, Last modification date: 2024-02-07)
Primary citation	Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Gangjee, A.,Devraj, R.,Queener, S.F.,Blakley, R.L. Comparison of ternary complexes of Pneumocystis carinii and wild-type human dihydrofolate reductase with coenzyme NADPH and a novel classical antitumor furo[2,3-d]pyrimidine antifolate. Acta Crystallogr.,Sect.D, 53:638-649, 1997 Cited by PubMed: 15299851 DOI: 10.1107/S090744499700509X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation