1DAJ

COMPARISON OF TERNARY COMPLEXES OF PNEUMOCYSTIS CARINII AND WILD TYPE HUMAN DIHYDROFOLATE REDUCTASE WITH COENZYME NADPH AND A NOVEL CLASSICAL ANTITUMOR FURO[2,3D]PYRIMIDINE ANTIFOLATE

1DAJ の概要

• エントリーDOI: 10.2210/pdb1daj/pdb
• 分子名称: DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE, ... (4 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: Pneumocystis carinii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25106.38

構造登録者

Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Gangjee, A.,Devraj, R.,Queener, S.F.,Blakley, R.L. (登録日: 1997-07-29, 公開日: 1997-12-24, 最終更新日: 2024-02-07)

• 主引用文献: Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Gangjee, A.,Devraj, R.,Queener, S.F.,Blakley, R.L.; Comparison of ternary complexes of Pneumocystis carinii and wild-type human dihydrofolate reductase with coenzyme NADPH and a novel classical antitumor furo[2,3-d]pyrimidine antifolate.; Acta Crystallogr.,Sect.D, 53:638-649, 1997; PubMed: 15299851; DOI: 10.1107/S090744499700509X

実験手法

X-RAY DIFFRACTION (2.3 Å)