1D96

MOLECULAR STRUCTURE OF R(GCG)D(TATACGC): A DNA-RNA HYBRID HELIX JOINED TO DOUBLE HELICAL DNA

1D96 の概要

• エントリーDOI: 10.2210/pdb1d96/pdb
• 分子名称: DNA/RNA (5'-R(*GP*CP*GP*)-D(*TP*AP*TP*AP*CP*GP*C)-3') (1 entity in total)
• 機能のキーワード: a-dna/rna, double helix, dna-rna hybrid
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 6186.01

構造登録者

Wang, A.H.-J.,Fujii, S.,Van Boom, J.H.,Van Der Marel, G.A.,Van Boeckel, S.A.A.,Rich, A. (登録日: 1992-10-17, 公開日: 1993-07-15, 最終更新日: 2024-02-07)

主引用文献

Wang, A.H.,Fujii, S.,van Boom, J.H.,van der Marel, G.A.,van Boeckel, S.A.,Rich, A.
Molecular structure of r(GCG)d(TATACGC): a DNA--RNA hybrid helix joined to double helical DNA.
Nature, 299:601-604, 1982

PubMed Abstract: The molecule r(GCG)d(TATACGC) is self-complementary and forms two DNA--RNA hybrid segments surrounding a central region of double helical DNA; its molecular structure has been solved by X-ray analysis. All three parts of the molecule adopt a conformation which is close to that seen in the 11-fold RNA double helix. The conformation of the ribonucleotides is partly determined by water molecules bridging between the ribose O2' hydroxyl group and cytosine O2. The hybrid-DNA duplex junction contains no structural discontinuities. However, the central DNA TATA sequence has some structural irregularities.

PubMed: 6181416
DOI: 10.1038/299601a0

実験手法

X-RAY DIFFRACTION (2 Å)