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1D8B

NMR STRUCTURE OF THE HRDC DOMAIN FROM SACCHAROMYCES CEREVISIAE RECQ HELICASE

Summary for 1D8B
Entry DOI10.2210/pdb1d8b/pdb
NMR InformationBMRB: 4445
DescriptorSGS1 RECQ HELICASE (1 entity in total)
Functional Keywordsfive helices, three-helical bundle flanked by two helices, dna binding protein
Biological sourceSaccharomyces cerevisiae (baker's yeast)
Cellular locationNucleus, nucleolus: P35187
Total number of polymer chains1
Total formula weight9385.96
Authors
Liu, Z.,Macias, M.J.,Bottomley, M.J.,Stier, G.,Linge, J.P.,Nilges, M.,Bork, P.,Sattler, M. (deposition date: 1999-10-21, release date: 2000-01-10, Last modification date: 2024-05-22)
Primary citationLiu, Z.,Macias, M.J.,Bottomley, M.J.,Stier, G.,Linge, J.P.,Nilges, M.,Bork, P.,Sattler, M.
The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins.
Structure Fold.Des., 7:1557-1566, 1999
Cited by
PubMed Abstract: The HRDC (helicase and RNaseD C-terminal) domain is found at the C terminus of many RecQ helicases, including the human Werner and Bloom syndrome proteins. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. However, the specific functional roles of these proteins in DNA recombination and replication are not known. An HRDC domain exists in both of the human RecQ homologues that are implicated in human disease and may have an important role in their function.
PubMed: 10647186
DOI: 10.1016/S0969-2126(00)88346-X
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

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