1D8B
NMR STRUCTURE OF THE HRDC DOMAIN FROM SACCHAROMYCES CEREVISIAE RECQ HELICASE
Summary for 1D8B
Entry DOI | 10.2210/pdb1d8b/pdb |
NMR Information | BMRB: 4445 |
Descriptor | SGS1 RECQ HELICASE (1 entity in total) |
Functional Keywords | five helices, three-helical bundle flanked by two helices, dna binding protein |
Biological source | Saccharomyces cerevisiae (baker's yeast) |
Cellular location | Nucleus, nucleolus: P35187 |
Total number of polymer chains | 1 |
Total formula weight | 9385.96 |
Authors | Liu, Z.,Macias, M.J.,Bottomley, M.J.,Stier, G.,Linge, J.P.,Nilges, M.,Bork, P.,Sattler, M. (deposition date: 1999-10-21, release date: 2000-01-10, Last modification date: 2024-05-22) |
Primary citation | Liu, Z.,Macias, M.J.,Bottomley, M.J.,Stier, G.,Linge, J.P.,Nilges, M.,Bork, P.,Sattler, M. The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins. Structure Fold.Des., 7:1557-1566, 1999 Cited by PubMed Abstract: The HRDC (helicase and RNaseD C-terminal) domain is found at the C terminus of many RecQ helicases, including the human Werner and Bloom syndrome proteins. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. However, the specific functional roles of these proteins in DNA recombination and replication are not known. An HRDC domain exists in both of the human RecQ homologues that are implicated in human disease and may have an important role in their function. PubMed: 10647186DOI: 10.1016/S0969-2126(00)88346-X PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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