1D8B

NMR STRUCTURE OF THE HRDC DOMAIN FROM SACCHAROMYCES CEREVISIAE RECQ HELICASE

1D8B の概要

• エントリーDOI: 10.2210/pdb1d8b/pdb
• NMR情報: BMRB: 4445
• 分子名称: SGS1 RECQ HELICASE (1 entity in total)
• 機能のキーワード: five helices, three-helical bundle flanked by two helices, dna binding protein
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast)
• 細胞内の位置: Nucleus, nucleolus: P35187
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9385.96

構造登録者

Liu, Z.,Macias, M.J.,Bottomley, M.J.,Stier, G.,Linge, J.P.,Nilges, M.,Bork, P.,Sattler, M. (登録日: 1999-10-21, 公開日: 2000-01-10, 最終更新日: 2024-05-22)

主引用文献

Liu, Z.,Macias, M.J.,Bottomley, M.J.,Stier, G.,Linge, J.P.,Nilges, M.,Bork, P.,Sattler, M.
The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins.
Structure Fold.Des., 7:1557-1566, 1999

PubMed Abstract: The HRDC (helicase and RNaseD C-terminal) domain is found at the C terminus of many RecQ helicases, including the human Werner and Bloom syndrome proteins. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. However, the specific functional roles of these proteins in DNA recombination and replication are not known. An HRDC domain exists in both of the human RecQ homologues that are implicated in human disease and may have an important role in their function.

PubMed: 10647186
DOI: 10.1016/S0969-2126(00)88346-X

実験手法

SOLUTION NMR