1D7A

CRYSTAL STRUCTURE OF E. COLI PURE-MONONUCLEOTIDE COMPLEX.

1D7A の概要

• エントリーDOI: 10.2210/pdb1d7a/pdb
• 関連するPDBエントリー: 1QCZ
• 分子名称: PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE, 5-AMINOIMIDAZOLE RIBONUCLEOTIDE (3 entities in total)
• 機能のキーワード: three-layer (alpha-beta-alpha) sandwich n5-cair mutase (pure), aminoimidazole ribonucleotide (air), lyase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 138091.74

構造登録者

Mathews, I.I.,Kappock, T.J.,Stubbe, J.,Ealick, S.E. (登録日: 1999-10-16, 公開日: 1999-12-03, 最終更新日: 2024-11-20)

主引用文献

Mathews, I.I.,Kappock, T.J.,Stubbe, J.,Ealick, S.E.
Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway.
Structure Fold.Des., 7:1395-1406, 1999

PubMed Abstract: Conversion of 5-aminoimidazole ribonucleotide (AIR) to 4-carboxyaminoimidazole ribonucleotide (CAIR) in Escherichia coli requires two proteins - PurK and PurE. PurE has recently been shown to be a mutase that catalyzes the unusual rearrangement of N(5)-carboxyaminoimidazole ribonucleotide (N(5)-CAIR), the PurK reaction product, to CAIR. PurEs from higher eukaryotes are homologous to E. coli PurE, but use AIR and CO(2) as substrates to produce CAIR directly.

PubMed: 10574791
DOI: 10.1016/S0969-2126(00)80029-5

実験手法

X-RAY DIFFRACTION (2.5 Å)