1D5W

PHOSPHORYLATED FIXJ RECEIVER DOMAIN

1D5W の概要

• エントリーDOI: 10.2210/pdb1d5w/pdb
• 分子名称: TRANSCRIPTIONAL REGULATORY PROTEIN FIXJ, SULFATE ION (3 entities in total)
• 機能のキーワード: doubly wound five-stranded beta/alpha fold, phosphorylated protein, nitrogen fixation regulation, gene regulation
• 由来する生物種: Sinorhizobium meliloti
• 細胞内の位置: Cytoplasm (Probable): P10958
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 42264.21

構造登録者

Birck, C.,Mourey, L.,Gouet, P.,Fabry, B.,Schumacher, J.,Rousseau, P.,Kahn, D.,Samama, J.P. (登録日: 1999-10-12, 公開日: 2000-10-11, 最終更新日: 2021-11-03)

主引用文献

Birck, C.,Mourey, L.,Gouet, P.,Fabry, B.,Schumacher, J.,Rousseau, P.,Kahn, D.,Samama, J.P.
Conformational changes induced by phosphorylation of the FixJ receiver domain.
Structure Fold.Des., 7:1505-1515, 1999

PubMed Abstract: A variety of bacterial adaptative cellular responses to environmental stimuli are mediated by two-component signal transduction pathways. In these phosphorelay cascades, histidine kinases transphosphorylate a conserved aspartate in the receiver domain, a conserved module in the response regulator superfamily. The main effect of this phosphorylation is to alter the conformation of the response regulator in order to modulate its biological function. The response regulator FixJ displays a typical modular arrangement, with a phosphorylatable N-terminal receiver domain and a C-terminal DNA-binding domain. In the symbiotic bacterium Sinorhizobium meliloti, phosphorylation of this response regulator activates transcription of nitrogen-fixation genes.

PubMed: 10647181
DOI: 10.1016/S0969-2126(00)88341-0

実験手法

X-RAY DIFFRACTION (2.3 Å)