1D59

CRYSTAL STRUCTURE OF 4-STRANDED OXYTRICHA TELOMERIC DNA

Summary for 1D59

• Entry DOI: 10.2210/pdb1d59/pdb
• Descriptor: DNA (5'-D(*GP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3') (1 entity in total)
• Functional Keywords: u-dna, quadruple helix, tetraplex, loop, dna
• Total number of polymer chains: 4
• Total formula weight: 15221.84

Authors

Kang, C.,Zhang, X.,Ratliff, R.,Moyzis, R.,Rich, A. (deposition date: 1992-02-25, release date: 1993-04-15, Last modification date: 2024-02-07)

Primary citation

Kang, C.,Zhang, X.,Ratliff, R.,Moyzis, R.,Rich, A.
Crystal structure of four-stranded Oxytricha telomeric DNA.
Nature, 356:126-131, 1992

PubMed Abstract: The sequence d(GGGGTTTTGGGG) from the 3' overhang of the Oxytricha telomere has been crystallized and its three-dimensional structure solved to 2.5 A resolution. The oligonucleotide forms hairpins, two of which join to make a four-stranded helical structure with the loops containing four thymine residues at either end. The guanine residues are held together by cyclic hydrogen bonding and an ion is located in the centre. The four guanine residues in each segment have a glycosyl conformation that alternates between anti and syn. There are two four-stranded molecules in the asymmetric unit showing that the structure has some intrinsic flexibility.

PubMed: 1545863
DOI: 10.1038/356126a0

Experimental method

X-RAY DIFFRACTION (2.3 Å)