1D59

CRYSTAL STRUCTURE OF 4-STRANDED OXYTRICHA TELOMERIC DNA

1D59 の概要

• エントリーDOI: 10.2210/pdb1d59/pdb
• 分子名称: DNA (5'-D(*GP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3') (1 entity in total)
• 機能のキーワード: u-dna, quadruple helix, tetraplex, loop, dna
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 15221.84

構造登録者

Kang, C.,Zhang, X.,Ratliff, R.,Moyzis, R.,Rich, A. (登録日: 1992-02-25, 公開日: 1993-04-15, 最終更新日: 2024-02-07)

主引用文献

Kang, C.,Zhang, X.,Ratliff, R.,Moyzis, R.,Rich, A.
Crystal structure of four-stranded Oxytricha telomeric DNA.
Nature, 356:126-131, 1992

PubMed Abstract: The sequence d(GGGGTTTTGGGG) from the 3' overhang of the Oxytricha telomere has been crystallized and its three-dimensional structure solved to 2.5 A resolution. The oligonucleotide forms hairpins, two of which join to make a four-stranded helical structure with the loops containing four thymine residues at either end. The guanine residues are held together by cyclic hydrogen bonding and an ion is located in the centre. The four guanine residues in each segment have a glycosyl conformation that alternates between anti and syn. There are two four-stranded molecules in the asymmetric unit showing that the structure has some intrinsic flexibility.

PubMed: 1545863
DOI: 10.1038/356126a0

実験手法

X-RAY DIFFRACTION (2.3 Å)