1D4Y

HIV-1 PROTEASE TRIPLE MUTANT/TIPRANAVIR COMPLEX

1D4Y の概要

• エントリーDOI: 10.2210/pdb1d4y/pdb
• 関連するPDBエントリー: 1D4S
• 分子名称: PROTEIN (HIV-1 PROTEASE), N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE (3 entities in total)
• 機能のキーワード: hydrolase, acid protease, aspartyl protease
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22212.28

構造登録者

Watenpaugh, K.D.,Janakiraman, M.N. (登録日: 1999-10-06, 公開日: 1999-10-13, 最終更新日: 2024-02-07)

• 主引用文献: Thaisrivongs, S.,Skulnick, H.I.,Turner, S.R.,Strohbach, J.W.,Tommasi, R.A.,Johnson, P.D.,Aristoff, P.A.,Judge, T.M.,Gammill, R.B.,Morris, J.K.,Romines, K.R.,Chrusciel, R.A.,Hinshaw, R.R.,Chong, K.T.,Tarpley, W.G.,Poppe, S.M.,Slade, D.E.,Lynn, J.C.,Horng, M.M.,Tomich, P.K.,Seest, E.P.,Dolak, L.A.,Howe, W.J.,Howard, G.M.,Watenpaugh, K.D.; Structure-based design of HIV protease inhibitors: sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors.; J.Med.Chem., 39:4349-4353, 1996; PubMed: 8893827; DOI: 10.1021/jm960541s

実験手法

X-RAY DIFFRACTION (1.97 Å)