1D4R

29-mer fragment of human srp rna helix 6

Summary for 1D4R

Entry DOI	10.2210/pdb1d4r/pdb
Descriptor	29-MER OF MODIFIED SRP RNA HELIX 6, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	a-rna helix, ggag/gagg bulge, ac/ca tandem mismatch, gu wobble base pairs, 2'3' -cyclic phosphate, rna
Total number of polymer chains	3
Total formula weight	28649.46
Authors	Wild, K.,Weichenrieder, O.,Leonard, G.A.,Cusack, S. (deposition date: 1999-10-05, release date: 1999-12-02, Last modification date: 2024-02-07)
Primary citation	Wild, K.,Weichenrieder, O.,Leonard, G.A.,Cusack, S. The 2 A structure of helix 6 of the human signal recognition particle RNA Structure Fold.Des., 7:1345-1352, 1999 Cited by PubMed Abstract: The mammalian signal recognition particle (SRP) is an essential cytoplasmic ribonucleoprotein complex involved in targeting signal-peptide-containing proteins to the endoplasmic reticulum. Assembly of the SRP requires protein SRP19 to bind first to helix 6 of the SRP RNA before the signal-peptide-recognizing protein, SRP54, can bind to helix 8 of the RNA. Helix 6 is closed by a GGAG tetraloop, which has been shown to form part of the SRP19-binding site. PubMed: 10574798 DOI: 10.1016/S0969-2126(00)80024-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation